YONSEI University K-NIBRT Education Center

Professor of K-NIBRT

Kim, InKyu

Professor dedicated to the project

ikkim@yonsei.ac.kr
inkyukim0316@naver.com
032-713-9849
211, Bioprocessing Technology Training Center, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, Republic of Korea

Institute

K-NIBRT Professor

Academic background

Kyung Hee University
Master's Degree at Kyung Hee University Graduate School
Doctor's Degree at Kyung Hee University Graduate School

Work experience

2014–2016Administrator of Ministry of Food and Drug Safety Gyeongin Branch
2013–2014Administrator of Director of Ministry of Food and Drug Safety Daegu Branch
2000–2013Director of Ministry of Food and Drug Safety
2000–2002Visiting scientist at the College of Pharmacy at Utah State University
1982–2000Korea National Institute of Health (researcher) and Ministry of Food and Drug Safety (researcher)
1994–1995Visiting scientist to the FDA
Acquired national pharmacist license
Acquired national oriental medicine pharmacist license
Acquired administrator’s certificate

Lecture history

Visiting Professor, Department of Cosmetics/Songdo Bio, Incheon at Incheon Jaeneung University
Adjunct Professor in the Department of Pharmacy/Pharmaceutical Science at Kyung Hee University

Professor of K-NIBRT

Doona Song

K-NIBRT Professor

doona.s@yonsei.ac.kr
032-713-9857
213, Bioprocessing Technology Training Center, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, Republic of Korea

Education

Bachelor's degree in Biotechnology, Yonsei University
Ph.D. in Biotechnology, Yonsei University

Professional Experience

2021-2023Visiting Professor, College of Pharmacy, Yonsei University ( Specializing in the Graduate Program for Pharmaceutical Industry Cooperation, with a focus on new drug research)
2020-2021Senior Researcher, STU Bio (Research and Development, Pharmaceutical Synthesis)
2019-2019Lecturer, School of Dentistry, Yonsei University (Organic Chemistry)
2016-2019Research Manager, Industry-Academia Cooperation Office, Yonsei University (Successfully secured projects for nurturing future scholars)
2013-2020Postdoctoral Researcher, Industry-Academia Cooperation Office, Yonsei University (Engaged in pharmaceutical design and synthesis across various research projects in the Molecular Pharmacology Laboratory)

Major Research Achievements

Optimization techniques for leading compounds
AI-based research on new drug design
In silico/in vitro studies for ADME optimization of small molecules

Participation in Research Projects

Production and properties study of anti-HIV candidate substances targeting HIV-NC
Design and synthesis of novel small molecules inducing functional regulation of bone marrow-derived mesenchymal stem cells for cardiovascular disease treatment
Construction of a library of inhibitors targeting human Leucyl-tRNA synthetase and development of anticancer agents
Chemical biology research on the effects of small molecules regulating the function of the ion exchange channel pendrin for congenital deafness and hypertension treatment
Investigation of the pharmacological characteristics of small molecules inhibiting the function of the ion exchange channel pendrin for congenital deafness treatment (Research Fellow Project)
Development of a PDS correction agent for congenital deafness treatment
Optimization study for KCNQ4 activators for the development of a therapy for noise-induced hearing loss.

Technology Transfer

2021Research collaboration and license agreement (연세의료원-아보메드)

Research Paper

2023Structural optimization of novel Ras modulator for treatment of Colorectal cancer by promoting β-catenin and Ras degradation
2022Inhibition of phospholipase D1 induces immunogenic cell death and potentiates cancer immunotherapy in colorectal cancer
2022Indirubin-3′-alkoxime derivatives for upregulation of Wnt signaling through dual inhibition of GSK-3β and the CXXC5-Dvl interaction
2021Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction
2020Inhibition of Pendrin by a small molecule reduces Lipopolysaccharide-induced acute Lung Injury
2020PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation
2020Identification and Validation of VEGFR2 Kinase as a Target of Voacangine by a Systematic Combination of DARTS and MSI biomolecules
2019Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma
2017Improving potency and metabolic stability by introducing an alkenyl linker to pyridine-based histone deacetylase inhibitors for orally available RUNX3 modulators
20152-(Trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate promotes megakaryocytic differentiation of myeloid leukaemia cells and primary human CD34+ haematopoietic stem cells
2013New synthetic aliphatic sulfonamido-quaternary ammonium salts as anticancer chemotherapeutic agents
2011, 2013Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy
2010Structure Based Optimization of Chromen-Based TNF-alpha Converting Enzyme (TACE) Inhibitors on S1' Pocket and Their Quantitative Structure Activity Relationship (QSAR) Study

Patents

Composition and method for the prevention or treatment of respiratory diseases
Novel rodanin derivatives, their manufacturing method, and pharmaceutical compositions for AIDS prevention or treatment containing them as active ingredients
Novel diamine compounds or pharmaceutically acceptable salts thereof, their manufacturing method, and pharmaceutical compositions for cancer treatment containing them
Novel thio- or urea derivatives, their manufacturing method, and pharmaceutical compositions for AIDS prevention or treatment containing them as active ingredients
Preparation of diamine derivatives as anticancer agents

Professor of K-NIBRT

Hongchul Yoon

K-NIBRT Professor

hcyoon@yonsei.ac.kr
032-713-9853
212, Bioprocessing Technology Training Center, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, Republic of Korea

EDUCATION

2011Yonsei University, Department of Biotechnology, Republic of Korea Ph.D. in Medicinal chemistry
1996Korea University, Department of Biotechnology, Republic of Korea M.S. in Biochemistry
1994Korea University, Department of Biotechnology, Republic of Korea B.S. in Biotechnology

Major Research Achievements

2023–2024Yunovia Pharm. Managing Director, Head of Innovative Solution Group
2016–2023Ildong Pharma. Managing Director, Head of Innovative Solution Group
2012–2016CalIBR(California Institute for Biomedical Research, CA, US) Research Scientist
1996–2012Daewoong Pharma. Research fellow, Department of Drug discovery

Research Paper(last 3-years only)

2023Synthetic Strategies for Improving Solubility: Optimization of Novel Pyrazolo[1,5-a]pyrimidine CFTR Activator That Ameliorates Dry Eye Disease. Journal of Medicinal Chemistry (ACS publicatin
2023Discovery of ID110521156, a Small Molecule GLP-1 Receptor Agonist, for the Treatment of Type 2 Diabetes and Obesity. ADA 83th Scientific sessions poster (American Diabetes association)
2022Novel CFTR Activator Cact-3 Ameliorates Ocular Surface Dysfunctions in Scopolamine- Induced Dry Eye Mice. International Journals of Molecular Sciences (MDPI)
2021Discovery of 5-(N-hydroxy carbamimidoyl) benzofuran derivatives as novel indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Bioorganic & Medicinal Chemistry Letters (Elsevier)

Patents(last 3-years PCT only)

WO 2024/085661A1Novel triheterocyclic compounds
WO 2024/063576A1Novel quinazoline compound as KRAS inhibitor
WO 2024/063578A1Novel tetraheterocycle compound
WO 2024/019541A1Heteroaryl derivative compound and use thereof
WO 2024/014885A1Novel Bicyclic heteroaryl compound and use thereof
WO 2023/182869A1Novel salt of GLP-1receptor agonist compound, preparation method thereof and pharmaceutical composition thereof
WO 2023/113474A1Novel salt of1-sulfonyl pyrrole derivative, Method for preparing same, and Pharmaceutical composition including same
WO 2023/113458A1Novel salt of1-sulfonyl pyrrole derivative, preparation method thereof and pharmaceutical comprising thereof
WO 2023/067388A1Uses of CFTR modulatorand/or PDE4 inhibitor compounds
WO 2022/231357A1Pharmaceutical comprising GPR40 agonist and SGLT-2 inhibitor
WO 2022/195522A1Inhibitors of ANO6 and their uses thereof
WO 2022/157686A1Inhibitors of Anoctamin6 protein and their uses thereof
WO 2022/123319A1Biased agonists of opioid receptors
WO 2022/084741A1CFTR modulator compounds, compositions, and uses thereof

Adjunct Professor of K-NIBRT

Sunhee Park

Professor

sueniepark@biowavew.com
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Education

Ph.D. in Microbiology, Washington State University
M.S. in Microbiology, Seoul National University
B.S. in Biology, Sogang University

Professional Experience

Member, WHO Coronavirus Vaccine Evaluation PWG
Ombudsman, Korea Health Industry Development Institute (KHIDI) R&D
Adjunct Lecturer, KNIBRT Biopharmaceutical Program (participated in ADB and WHO talent training programs, lectures, and practical training, 2022)
Legal Director, Korean Society for Microbiome
Committee Member, Catholic University Industry-Academic Cooperation Foundation
Committee Member, Ministry of Food and Drug Safety (MFDS) in various divisions, including Vaccines/Blood Products, Cell and Gene Therapy, GMP, and Microbiome
2019.04-presentCEO, BioWave W
2020-2021Senior Advisor, SINEK Inc.
2018.03-2019.08Full-time Professor, Hallym University Industry-Academic Cooperation Foundation
2016.02-2021.02Head of Global Expansion Support Division, MFDS Bio-Pharmaceutical Association Dynamic Bio Program
2013.10-2018.02Vice President/Head of Research Institute, EuBiologics and Adbiotech Co., Ltd.
1999.07-2013.09Director of Analysis Center, MFDS (Jul. 1999 – Sep. 2013), overseeing vaccine, viral product, blood product divisions, among others
1987.05-1999.07Senior Researcher & Director, KRIBB and KIST, specializing in virus and oncology research

Awards & Honors

Order of Science and Technology Merit (2003, Virus Immunology Research)
Minister of Health and Welfare Award (2013, Excellence in MFDS Operations)
Commissioner’s Award, MFDS (2017, WHO PQ vaccine registration, UNICEF supply contributions)
Commissioner’s Award, MFDS (2018, Bio-Industry Strategic Planning Committee Leadership)
Director’s Award, MFDS Biopharmaceuticals Bureau (2019, Global Expansion Support Leadership)
1st Contribution Award, Center for Women in Science, Engineering and Technology (2013)
1st Contribution Award, EuBiologics Co., Ltd. (2016)

International Experience

Listed in Who’s Who in the World (2011–2014)
Coordinator for Korea-U.S. FDA NCTR/NITR MOU and Joint Symposiums (2007 & 2008)
Coordinator for Korea-Japan NIHS/NITR Joint Symposium, Tokyo
Expert Committee Member, WHO EAP Biostandards (2005–2009)
OECD/IPCS Toxicogenomics Program Advisor (2006–2008)
OECD Molecular Screening & Toxicogenomics Program Advisor (2008–), Chair of Epigenetics Division
Board Member, International Papillomavirus Society (2004–2014)

Domestic Activities

Head of Global Expansion Support Division, Dynamic Bio Program, MFDS (2016–2021)
WHO Committee Member, MFDS Bio-Industry Development Strategy Task Force (2016–Present)
Legal Director, Korean Society for Microbiome (2018–Present)
Member, National Center for Science & Technology Diplomacy (2017)
Central Pharmaceutical Review Committee Member, MFDS (2014)
Expert Advisor, Korea Disease Control and Prevention Agency (2013)
Adjunct Professor at Sungkyunkwan University (2014–2021), Korea University (2003–2013), Sogang University (2001–2003), and Hallym University

Publications & Notable Contributions

Authored over 150 research papers and multiple books
Currently engaged in supporting development projects involving coronavirus vaccines, CAR-T therapies, antibody immuno-oncology drugs, microbiome pharmaceuticals, and general oncology drugs

K-NIBRT Professor

Jiyoung Son

K-NIBRT Professor

jyson@yonsei.ac.kr
032-713-9847
216, Bioprocessing Technology Training Center, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, Republic of Korea

EDUCATION

2015-2021 Ph.D Pharmacy. CHA University Graduate School
2000-2003 M.S Dairy Science. Chungnam National University Graduate School
1994-1999 B.S. Dairy Science. Chungnam National University

EMPLOYMENT HISTORY

2025-CurrentK-NIBRT Professor
2021-2024Enbios Inc.
2020-2021AmicogenPharma Inc.
2015-2018Pharmaresearch BIO Inc.
2012-2014Hanwhapharmaceutics Inc.
2007-2012Aprogen
1999-2006DB Group Inc.

RESEARCH ACTIVITY

GRANTS

Date : 07/01/2021 – 06/30/2023
Project title : Developing multiple anticancer drugs (platform) with efficacy / non-toxicity / persistence
Date : 04/01/2022 – 12/31/2023
Project title : Development and standardization of green algae-derived immune-based atopy improvement substances
Date : 05/01/2023 – 12/31/2023
Project title : Development and commercialization of atopic dermatitis treatment material from black bamboo leaves
Date : 11/01/2021 – 10/31/2023
Project title : Development of thrombolytic therapy or multi-modal treatment for ischemic stroke
Date : 04/01/2018 – 12/31/2020
Project title : Development of an oral treatment for age related macular degeneration by using YSB201 for the approval of clinical phase 1
Date : 04/01/2017 – 12/31/2019
Project title : Development of functional food materials using sea squirt-derived vanadium
Date : 01/01/2018 –12/31/2018
Project title : Development of functional new food substances for body fat reduction and analysis
Date : 05/15/2014 – 11/30/2016
Project title : Research on the advancement for Standards and Specifications of Biological products
Date : 04/01/2008 – 03/31/2012
Project title : Structural and Functional Studies on Cell Membrane Proteome of Human Mesenchymal Stem Cells

About Us

Faculty Introduction

Professor of K-NIBRT

Adjunct Professor of K-NIBRT