K-NIBRT

Institute

• Yonsei University College of Life Science and Biotechnology, Dept. of Biotechnology
• Director of K-NIBRT Education Center

Academic background

• 1992-1997Ph.D. Department of Chemistry, Pennsylvania State University
• 1988-1990M.s. Department of Medicinal Chemistry, Seoul National University
• 1984-1988B.s. Department of Pharmacy, Seoul National University

Work experience

• 2009-PresentProfessor, Department of the Integrated OMICS for Biomedical Sciences (WCU Program in Graduate School), Yonsei University
• 2008-PresentProfessor, Department of Biotechnology, Yonsei University Mar.
• 2020-2021Director, Research Institute of Integrated Biotechnology and Translational Medicine
• 2018-2020Chair Person, Korea Association of Pharmacy Education
• 2016-2018Senior Director, Korea Association of Pharmacy Education
• 2015-2021Dean, College of Pharmacy, Yonsei University
• 2014-2016Director, Division of Integrated Science and Engineering,Underwood International College, Yonsei University
• 2013-2015Associate Dean for Planning, Underwood International College, Yonsei University
• 2011-2013Head, Department of Biotechnology, Yonsei University

Awards and Honors

• 2010.04.The Prime Minister’s award for the Scientific Achievement and Promotion (in 43rd Korean National Science Day
• 2008The Best Teaching Award in 2008, Yonsei University
• 2014The Outstanding Research Award in 2014 (Research Grant), Yonsei University The Outstanding Reviewer in 2014, Bioorganic & Medicinal Chemistry
• 2014.07The Outstanding Reviewer in 2013, Journal of Medicinal Chemistry

Institute

• Vice chairperson for External Affairs of K-NIBRT
• Associate Professor, Global Leaders College

Academic background

• 1998-2004Ph.D. Department of Biotechnology, Yonsei University
• 1994-1998BS, Department of Biotechnology, Yonsei University

Work experience

• 2021-PresentAdjunct Professor, National Institute for Bioprocessing Research and Training, Yonsei University
• 2020-PresentAssociate Professor, Bio-Living Engineering Major, Global Leaders College, Yonsei University
• 2020-PresentAdjunct Professor, Graduate Program in Integrative Biotechnology & Translational Medicine, Yonsei University
• 2020-PresentCouncil Member, Chungcheongnam-do Future Business Discovery Council
• 2019-2020Senior Manager, Industrial Microbio Center, Bio R&D, CJ Cheiljedang Corp
• 2018-2019Senior Manager, Future Innovation Center, Food R&D, CJ Cheiljedang Corp
• 2004-2017Director, Advanced Material Research Center, Life Ingredient & Material R&D, CJ Cheiljedang Corp

POSITION

• Assistant Professor, Chair of Bio-Convergence
• Integrated Science Engineering Division, Underwood International College
• Yonsei University, Incheon, Korea

EDUCATION

• 2012-2019Yale University, New Haven, CT, USA
  Ph.D. in the Department of Immunobiology Advisor; Prof. Alfred L. M. Bothwell
• 2006-2008Yonsei University, Seoul, Korea
  M.S. in the Department of Biotechnology Advisor; Prof. Sang-Kyou Lee
• 2002-2006Yonsei University, Seoul, Korea
  B.S.E. in the Department of Biotechnology

PROFESSIONAL EXPERIENCES

• 2023-Present Yonsei University, Underwood International College, Incheon, Korea
  Chair of Bio-Convergence, Integrated Science and Engineering Division
• 2022 - 2023 Yale University, New Haven, CT, USA
  Adjunct Assistant Professor in the section of Endocrinology and Metabolism, Internal Medicine
• 2021 - 2022 Yale University, New Haven, CT, USA
  Postdoctoral Associate in the Department of Internal medicine, Section of Endocrinology and Metabolism, Advisor; Prof. John Wysolmerski
• 2019 - 2021 Yale University, New Haven, CT, USA
  Postdoctoral Associate in the Department of Immunobiology Advisor; Prof. Alfred L. M. Bothwell
• 2008 - 2012 National Cancer Center, Korea
  Research assistant in the Specific organ cancer branch Advisor; Prof. Kyungho Choi

Publications

• 2024 Park S, Kim J, Shin JH, Intercellular transfer of immune regulatory molecules via trogocytosis. Springer Nature 2024, Accepted
• 2024 Jeong J, Lee J, Talaia G, Kim W, Song J, Yoo K, Gonzalez DG, Athonvarangkul D, Shin JH, Dann P, Haberman AM, Kim LK, Ferguson SM, Choi J, Wysolmerski J. Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death during Mammary Gland Involution. Cellular and Molecular Life Sciences. 81(1) 1-17, 2024
• 2022 Lee HW, Shin JH, Simons M. Flow goes forward and cell steps backward: Endothelial migration. Experimental & Molecular Medicine 54, 711-719, 2022
• 2021 Shin JH*, Jeong J, Maher SE, Lee HW, Lim J and Bothwell AL. Colon cancer cells acquire immune regulatory molecules from tumor-infiltrating lymphocytes by trogocytosis. Proc Natl Acad Sci U S A. 118 (48), 2021 * First and Corresponding author
• 2021 Shin JH, Jeong J, Choi J, Lim J, Dinesh RK, Braverman J, Hong JY, Maher SE, Vesely MA, Kim WJ, Koo JH, Tang W, Wu D, Blackburn HN, Xicola RM, Llor X, Yilmaz O, Choi JM and Bothwell AL. Dickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1. iScience 24 (5), 102411, 2021

HONORS & AWARDS

• 2019 Distinguished Dissertation, 2019 Yale Graduate School of Arts and Sciences
• 2019 Best Poster Presentation Award, 2019 Yale Cancer Center Trainee Colloquium
• 2016 Best Presentation Award, Poster Presentation, 2016 KAI-IBS Joint International Conference
• 2011 Excellent Poster Award, Fall Conference of the Korean Association of Immunologist
• 2005 Honors Student Award, Yonsei University

POSITION

• 1993.3-1996.2Department of Life Science, Pohang University of Science and Technology (POSTECH), Pohang, Korea Ph. D
• 1991.3-1993.2Department of Life Science, Pohang University of Science and Technology (POSTECH), Pohang, Korea M. S
• 1987.9-1989.8Department of Biotechnology, Yonsei University, Seoul, Korea M. S
• 1983.3-1987.2Department of Biotechnology, Yonsei University, Seoul, Korea B. S

Research Experience

• 2010.09-2019.08Professor: Department of Molecular Biology, Pusan National University
• 2009.09-2010.08Visiting Associate Project Scientist: College of Medicine, University of California, San Diego (Dr. Olefsky JM lab)
• 2004.09-2010.08Associate Professor: Department of Molecular Biology, Pusan National University
• 1999.03-2004.08Instructor and Assistant professor: Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul, Korea
• 1998.05-1999.02 Research Professor: Department of Biochemistry, College of Medicine, Chungbuk National University, Cheongju, Korea
• 1996.06-1998.04Post-doctor: Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashiville, TN, U.S.A
• 1996.03-1996.05Post-doctor: Department of Life Science, Pohang University of Science and Technology, Pohang, Korea

Award received

• 2014.4.21Science and technology award given by Busan city
• 2003.04ILCHEON Young Scientist Award given by Korea Society of Biochemistry and Molecular Biology
• 2003.04Korea Science Best Research Award given by Korea Science and Engineering Association
• 2000.10Young Physiologist Award given by Korea Society of Physiology

Academic activity

• President, KSCB (Korean Society for Cell Biology) 2022.09 ~ 2023-08
• Director of KSBMB (Korean Society for Biochemistry and Molecular Biology) 2019.01.01 ~ 2019.12.31, 2022.01 ~ 2023.12.31
• Chairman of steering committee of KSBMB: 2019.01 ~ 2019.12, 2022. 01~2024.12
• Associate Editor of Exp. Mol. Med (IF:12.172): 2015.01 ~ present
• Editor of Mol Cells (IF:4.250): 2008.01 ~ present
• Editor of Am J Cancer Res (IF:6.166): 2011.01 ~ present
• Review Board of the Division of Life Sciences at the National Research Foundation of Korea: 2012.01 ~ 2015.12

Administrative position within University

• 2024.09~presentVice chairperson of Academic Administration in K-NIBRT
• 2024.03~2026.02Associate dean, Institute for Convergence Research and Education
• 2022.01~2025.12Chairperson in Institutional Animal Care and Use Committee (IACUC)
• 2018.01~2019.08Director of the Laboratory Animal Center at Pusan National University
• 2018.01~2019.08Chair of the Department of Molecular Biology at Pusan National University)
• 2016.01~2018.12Director of the Life Systems Research Institute at Pusan National University
• 2013.9~2015.08Associate Dean of the College of Natural Sciences at Pusan National University
• 2012.01~2015.12Review Board of the Division of Life Sciences at the National Research Foundation of Korea
• 2009.03~2019.08Adjunct Professor at the Regional Cancer Center, Pusan National University Hospital

Publications

• Song D, Lim SH, Kim Y, Lee H, Kim T, Lim H, Min DS, Han G. (2024) Development and evaluation of indole-based phospholipase D inhibitors for lung cancer immunotherapy. J. Med. Chem. In press.
• Lim SH, Lee H, Lee HJ, Kim K, Choi J, Han JM, Min DS. (2024) PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/-catenin pathways. Exp. Mol. Med. 56(7): 1479-1487
• Park JS, Yang S, Song D, Jeong HY, Kim SM, Choi J, Kang HY, Han G, Min DS, Cho ML, Park SH (2023) A newly developed PLD1 inhibitor ameliorates rheumatoid arthritis by regulating pathogenic T and B cells and inhibiting osteoclast differentiation. .Immunol Lett. 263:87-96. (co-corresponding author)
• Park SJ, Yoo HC, Ahn E, Luo E, Kim Y, Sung Y, Yu YC, Kim K, Min DS, Lee HS, Hwang GS, Ahn T, Choi J, Bang S, Han JM. (2023) Enhanced glutaminolysis drived hypoxia-induced chemoresistance in pancreatic cancer. Cancer Res. 83(5):735-752
• Hwang WC, Song D, Lee H, Oh C, Lim SH, Bae HJ, Kim ND, Han G, Min DS. (2022) Inhibition of phospholipase D1 induces immunogenic cell death and potentiates cancer immunotherapy in colorectal cancer. Exp. Mol. Med. 54(9):1563-1576.
• Vafaeinik F, Kum HJ, Jin SY, Min DS, Sing SH, Ha HK, Kim CD, Bae SS (2022) Regulation of epithelial-mesenchymal transition of A549 cells by prostaglandin D2. Cell Physiol Biochem, 56(2): 89-104
• Baek MO, Cho HJ, Min DS, Choi CS, Yoon MS (2022) Self-transducible LRS-UNE-L peptide enhances muscle regeneration. J. Cachexia Sarcopenia and Muscle. 13(2): 1277-1288
• Lee W, LJY, Lee HS, Yoo Y, Shin H, Kim H, Min DS, Bae JS, Seo YK (2021) Thermosensitive hydrogel harboring CD146/IGF-1 nanoparticles for skeletal-muscle regeneration. ACS Applied Bio Materials. 4(9), 7070-7080
• Lee H, Jung T.-Y., Lim SH, Choi EJ, Lee J, Min DS (2021) Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuon 1. Exp. Mol. Med. 53(9):1287-1297.
• Kang DW, Hwang WC, Noh YN, Che X, Lee SH, Jang Y, Choi KY, Choi JY, Min DS (2021) Deletion of phospholipase D1 decreases bone mass and increases fat mass via modulation of Runx2, β-catenin-osteoprotegerin, PPAR-γ and C/EBPα signaling axis. Biochim Biophys Acta- Mol Basis Dis. 1867(5):166084
• Riew TR, Kim S, Jin X, Kim HL, Hwang WC, Kang M, Yang ES, L MY, Min DS (2021) Cellular and subcellular localisation of endogenous phospholipase D6 in seminiferous tubules of mouse testes. Cell Tissue Res. 3865 (1), 191-205.
• Hwang WC, Seo SH, Kang M, Kang RH, Di Paolo G, Choi KY, Min DS. (2021) PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury. J. Cell Physiol. 236 (7): 5193-5211
• Lee H, Park S, Ju S, Kim S, Yoo JW, Yoon IS, Min DS, Jung Y. (2021) Preparation and Evaluation of Colon-Targeted Prodrugs of the Microbial Metabolite 3-Indolepropionic Acid as an Anticolitic Agent. Mol Pharm. 18(4):1730-1741.
• Kim MK, Hwang WC, Min DS (2021) Pleckstrin homology domain of phospholipase D2 is a negative regulator of focal adhesion kinase. BMB Rep. 54(2) 112-117
• Hwang WC, Kang DW, Kang Y, Jang Y, Kim JA, Min DS. (2020) Inhibition of phospholipase D2 augments histone deacetylase inhibitor-induced cell death in breast cancer cells. Biol Res. 1;53(1):34
• Lee SY, Lee YY, Choi JS, Kim KS, Min DS, Park SY, Han JS. (2020) Nitration of protein phosphatase 2A increases via Epac1/PLCε/CaMKII/HDAC5/iNOS cascade in human endometrial stromal cell decidualization. FASEB J. 4(11):14407-14423
• Ahmed M, Min DS, Kim D (2020) Curated gene expression dataset of differentiating 3T3-L1 adipocytes under pharmacological and genetic perturbations. Adipocyte. 9(1): 600-608.
• Kang DW, Hwang WC, Noh YN, Park KS, Min DS (2020) Phospholipase D1 inhibition sensitizes glioblastoma to temozolomide and suppresses its tumorigenicity. J Pathol. 252(3):304-316
• Shahriyar SA, Seo SU, Min KJ, Kubatka P, Min DS, Chang JS, Kim DE, Woo SM, Kwon TK. (2020) Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway. Cancers (Basel). 12(9):E2363
• Kang DW, Hwang WC, Noh YN, Kang Y, Jang Y, Kim JA, Min DS (2020) Phospholipase D1 is upregulated by vorinostat and confers resistance to vorinostat in glioblastoma. J Cell Physiol. 236(1):549-560.
• Ahmed M, Min DS, Kim DR. (2020) Integrating binding and expression data to predict transcription factors combined function. BMC Genomics. 21(1):610
• Kim S, Lee S, Lee H, Ju S, Park S, Kwon D, Yoo JW, Yoon IS, Min DS, Jung YS, Jung Y. (2020) A Colon-Targeted Prodrug, 4-Phenylbutyric Acid-Glutamic Acid Conjugate, Ameliorates 2,4-Dinitrobenzenesulfonic Acid-Induced Colitis in Rats. Pharmaceutics. 12(9): E843
• Yoo HJ, Hwang WC, Min DS (2020) Targeting of phospholipase D1 ameliorates collagen-induced arthritis via modulation of Treg and Th17 cell imbalance and suppression of osteoclastogenesis. Int J Mol Sci. 21(9):E3230
• Ro EJ, Cho YH, Jeong WJ, Park JC, Min DS, Choi KY. (2019) WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer. Cell Commun Signal. 2019 Jul 30;17(1):88
• Ryu WJ, Lee JE, Cho YH, Lee G, Seo MK, Lee SK, Hwang JH, Min DS, Noh SH, Paik S, Kim S, Cheong JH, Choi KY. A Therapeutic Strategy for Chemotherapy-Resistant Gastric Cancer via Destabilization of Both β-Catenin and RAS. Cancers (Basel). 2019 Apr 8;11(4).
• Jeong WJ, Park JC, Kim WS, Ro EJ, Jeon SH, Lee SK, Park YN, Min DS, Choi KY. (2019) WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation. Nat Commun. (IF: 12.353) 10(1):295
• Park J, Cho YH, Shin WJ, Lee SK, Lee J, Kim T, Cha PH, Yang JS, Cho J, Min DS, Han G, Lee HY, Choi KY. (2019) A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer. Scientific Reportes (IF: 4.122), 9(1):648
• Min DS (2018) Role of tumor-associated macrophage in tumor microenvironment. J Life Science. 28:992-998
• Lee SK, Cho YH, Cha PH, Yoon JS, Ro EJ, Jeong WJ, Park J, Kim H, Il Kim T, Min DS, Han G, Choi KY. (2018) A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab. Exp Mol Med. (IF:5.584) 50(11):153
• Lee SK, Jeong WJ, Cho YH, Cha PH, Yoon JS, Ro EJ, Choi S, Oh J, Heo Y, Kim H, Min DS, Han G, Lee W, Choi KY (2018) β-Catenin-RAS interaction serves as a molecular switch for RAS degradation via GSK3β. EMBO Report (IF: 8.568). 19(12). pii: e46060
• Kang DW, Suh YA, Jang SJ, Kim YM, Choi KY, Min DS (2017) Phospholipase D1 inhibition linked to up-regulation of ICAT blocks colorectal cancer growth hyperactivated by Wnt/β-catenin and PI3K/Akt signaling. Clinical Cancer Research. 1;23(23):7340-7350
• Kug Hwa Lee, Woo-Jeong Jeong, Pu-Hyeon Cha, Sang-Kyu Lee, Do Sik Min, Kang-Yell Choi (2017) Stabilization of Sur8 via PKC degradation promotes transformation and migration of colorectal cancer cells. Oncotarget. 8:115596-115608
• Yum S, Jeong S, Kim D, Lee S, Kim W, Yoo JW, Kim JA, Kwon OS, Kim DD, Min DS, Jung Y. (2017) Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase. Int J Mol Sci. 25;19(1)
• Bae SY, Byun S, Bae SH, Min DS, Woo HA, Lee K (2017) TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway. Autophagy. May 4;13(5):820-833
• Lee S, Jeong S, Kim W, Kim D, Yang Y, Yoon JH, Kim BJ, Min DS, Jung Y. (2017) Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5'-AMP-activated protein kinase. Biochem Biophys Res Commun. Jan 29;483(1):449-455
• Min DS (2016) A potential efficacy of rebamipide as anti-gastric cancer drug. J Life Science 26;1214-1217
• Kang DW, Yang ES, Noh YN, Hwang WC, Jo SY, Suh YA, Park WS, Choi KY, Min DS (2017) MicroRNA-320a and -4496 attenuate Helicobacter pylori CagA-induced cancer-initiating potential and chemo-resistance by targeting β-catenin and ABCG2. J Pathology. 241(5):614-625
• Kang DW, Lee SW, Hwang WC, Lee BH, Choi YS, Suh YA, Choi KY, Min DS. (2017) Phospholipase D1 acts through Akt/TopBP1 and RB1 to regulate the E2F1-dependent apoptotic program in cancer cells. Cancer Res. 77(1):142-152
• Hur JH, Park SY, Dall'Armi C, Lee JS, Di Paolo G, Lee HY, Yoon MS, Min DS, Choi CS. (2016) Phospholipase D1 deficiency in mice causes nonalcoholic fatty liver disease via an autophagy defect. Sci Rep.6:39170 (Cocorrsponding author)
• Park JC, Jeong WJ, Kim MY, Min DS, Choi KY. (2016) Retinoic-acid-mediated HRas stabilization induces neuronal differentiation of neural stem cells during brain development. J Cell Sci. 129:2997-3007.
• Cha PH, Cho YH, Lee SK, Lee J, Jeong WJ, Moon BS, Yun JH, Yang JS, Choi S, Yoon J, Kim HY, Kim MY, Kaduwal S, Lee W, Min DS, Kim H, Han G, Choi KY. (2016) Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat Chem Biol. 8:593-600
• Kang DW, Noh YN, Hwang WC, Choi KY, Min DS. (2016) Rebamipide attenuates Helicobacter pylori CagA-induced self-renewal capacity via modulation of β-catenin signaling axis in gastric cancer-initiating cells. Biochem Pharmacol. 113:36-44
• Kim MY, Kim HY, Hong J, Kim D, Lee H, Cheong E, Lee Y, Roth J, Kim DG, Min DS, Choi KY. (2016) CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation. Glia. 64:350-362.
• Moon J, Kaowinn S, Cho IR, Min DS, Myung H, Oh S, Kaewpiboon C, Kraemer OH, Chung YH. (2016) Hepatitis C virus core protein enhances hepatocellular carcinoma cells to be susceptible to oncolytic vesicular stomatitis virus through down-regulation of HDAC4. Biochem Biophys Res Commun. 474:428-434
• Lee JW, Kim LE, Shim HJ, Kim EK, Hwang WC, Min DS, Yu SW. (2016) A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation. Biochem Biophys Res Commun. 474:587-593
• Seo SH, Lee SH, Cha PH, Kim MY, Min DS, Choi KY. (2016) Polygonum aviculare L. and its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing. Phytother Res. 30:848-854
• Park MH, Choi KY, Min DS. (2015) The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5. Exp Mol Med. 47:e200
• Park MH, Bae SS, Choi KY, MinDS (2015) Phospholipase D2 promotes degradation of hypoxia-inducible factor-1independent of lipase activity. Exp. Mol. Med. 47:e196
• Kaduwal S, Jeong WJ, Park JC, Lee KH, Lee YM, Jeon SH, Lim YB, Min DS, Choi KY. (2015) Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling. Oncotarget. 6:33091-330105.
• Kang DW, Choi CY, Cho YH, Tian H, Paolo G, Choi KY, Min DS (2015) Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling b-catenin signaling in cancer-initiating cells. J Exp. Med. 212;1219-1237.
• Lee, S-H. , Kim, M-Y, Kim, H-Y. Lee, Y.-M. Kim, H. Nam, K. A. Roh, MR , Min DS, .Y, and Choi, K.Y. (2015) The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. J Exp.Med. 212;1061-1080
• Koo KH, Jeong WJ, Cho YH, Park JC, Min DS, Choi KY (2015) K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis. Oncotarget. 6;21328-21340.
• Hwang JH, Cha PH, Han G, Bach TT, Min DS, Choi KY. (2015) Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/β-catenin pathway activation. Exp. Mol. Med. 47:e152
• Kim HY, Yoon JY, Yun JH, Cho KW, Lee SH, Rhee YM, Jung HS, Lim HJ, Lee H, Choi J, Heo JN, Lee W, No KT, Min DS, Choi KY (2015) CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation. Cell Death Diff. 22:912-920
• 158. Han S, Huh J, Kim W, Jeong S, Min DS, Jung Y. (2014) Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid. Exp Mol Med. 2014 Dec 19;46:e126. Co-(Co-corresponding authors)
• Park MH, Choi KY, Jung Y, Min DS (2014) Phospholipase D1 protein coordinates dynamic assembly of HIF-1a-PHD-VHL regulate HIF-1a stability. Oncotarget. 5(23) 11857-11872
• Hwang WH, Kin MK, Choi KY, Min DS. (2014) Inhibition of phospholipase D2 induces autophagt in colorectal cancer cells. Exp. Mol. Med. Dec 5, 46:e124
• Bae EJ, Lee HJ, Jang YH, Michael S, Masliah E, Min DS, Lee SJ. (2014) Cell Death Differ. Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates. 21(7):1132-41
• Kang DW, Choi KY, Min DS (2014) Functional Regulation of Phospholipase D Expression in Cancer and Inflammation. J Biol Chem. 289(33):22575-22582
• Lee SH, Nam JK, Park JK, Lee JH, Min DS, Kuh HJ. (2014) Differential protein expression and novel biomarkers related to 5-FU resistance in a 3D colorectal adenocarcinoma model. Oncol Rep. 32(4):1427-34
• Cha PH, Shin W, Zahoor M, Kim HY, Min DS, Choi KY. (2014) Hovenia dulcis Thunb Extract and Its Ingredient Methyl Vanillate Activate Wnt/β-Catenin Pathway and Increase Bone Mass in Growing or Ovariectomized Mice. PLoS One. 22;9(1):e85546
• Jang YH, Choi KY, Min DS. (2014) Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy. Cell Death Differ. 21 (4):533-546
• Moon BS, Jeong WJ, Park J, Kim TI, Min DS, Choi KY (2014) Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/-catenin signaling. J. Natl. Cancer Institute. 106 (2):djt373.
• Choi OM, Cho YH, Choi S, Lee SH, Seo SH, Kim HY, Han G, Min DS, Park T, Choi KY (2014) The small molecule indirubin-3'-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity. Int J Obes (Lond). 38(8):1044-52
• Kim HY, Yang DH, Shin SW, Kim MY, Yoon JH, Kim S, Park HC, Kang DW, Min DS, Hur MW, Choi KY (2014) CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation. FASEB J. 28(2):615-26
• Zahoor M, Cha PH, Min DS, Choi KY (2014) Indirubin-3'-Oxime Reverses Bone Loss in Ovariectomized, Hindlimb-Unloaded Mice via Activation of the Wnt/β-Catenin Signaling. J Bone Miner Res. 29(5), 1196-1205
• Park MH, Kang DW, Jung Y, Choi KY, Min DS.(2013) Caffeic acid phenethyl ester downregulates phospholipase D1 via direct binding and inhibition of NFκB transactivation. Biochem Biophys Res Commun. 442:1-7
• Son JC, Kang DW, Yang KM, Choi KY, Son TG, Min DS (2013) Phospholipase D inhibitor enhances radiosensitivity of breast cancer. Exp. Mol. Med. 45:e38
• Kang DW, Park MK, Oh HJ, Lee DG, Park SH, Choi KY, Cho ML, Min DS. (2013) Phospholipase D1 Has a Pivotal Role in Interleukin-1β-Driven Chronic Autoimmune Arthritis through Regulation of NF-κB, Hypoxia-Inducible Factor 1α, and FoxO3a. Mol Cell Biol. 33(14):2760-2772
• Kang DW, Hwang WC, Park MH, Ko GH, Ha WS, Kim KS, Lee YC, Choi KY and Min DS. (2013) Rebamipide abolishes Helicobacter pylori CagA-induced Phospholipase D1 expression via inhibition of NFκB and suppresses invasion of gastric cancer cells. Oncogene. 32:3531-3542
• Jang YH, Min DS (2012) The hydrophobic amino acids involved in the interdomain association of PLD1 regulate the shuttling of PLD1 from vesicular organelles into the nucleus. Exp. Mol. Med. 44(10) 571-577
• Lee SH, Zahoor M, Hwang JK, Min DS, Choi KY. (2012) Valproic Acid induces cutaneous wound healing in vivo and enhances keratinocyte motility. PLoS One. 2012;7(11):e48791.
• Ahn MY, Kang DO, Na YJ, Yoon S, Choi WS, Kang KW, Chung HY, Jung JH, Min DS, Kim HS. (2012) Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing. Cancer Lett. 325(2) 189-199
• Hong SC, Yum SH, Yoo HJ, Kang SK, Yoon JH, Min DS, Kim YM, Jung YJ (2012) Colon-targeted cell permeable NFkB inhibitory peptide is orally against experimental colitis. Mol. Pharmaceutics. 9:1310-1319
• Lee SH, Yoon J, Shin SH, Zahoor M, Kim HJ, Park PJ, Park WS, Min DS, Kim HY, Choi KY. (2012) Valproic Acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells. PLoS One. 7(4):e34152
• Jang YH, Min DS (2012) Intermolecular association between caspase-mediated cleavage fragments of phospholipase D1 protects against apoptosis. Int. J. Biochem. Cell Biol. 44(2): 358-365
• Park MK, Her YM, Cho ML, Oh HJ, Park EM, Kwok SK, Ju JH, Park KS, Min DS, Kim HY, Park SH. (2011) IL-15 promotes osteoclastogenesis via the PLD pathway in rheumatoid arthritis. Immunol Lett. 139(1-2):42-51.
• Lee YH, Uhm JS, Yoon SH, Kang JY, Kim EK, Kang BS, Min DS, Bae YS (2011) The C-terminal domain of PLD2 participates in degradation of protein kinase CKII Β subunit in human colorectal carcinoma cells. BMB Rep. 44(9):572-7
• Park MH, Min DS. (2011) Quercetin-induced downregulation of phospholipase D1 inhibits proliferation and invasion in U87 glioma cells, Biochem. Biophys. Res. Commun. 412(4) 710-715
• Lee YJ, Ahn MY, Kim HS, Kwack SJ, Park KL, Yoon S, Min DS. (2011) Role of phospholipase D in regulation of testicular Leydig cell hyperplasia in Sprague-Dawley rats treated with di(2-ethylhexyl) phthalate. Arch. Toxicol. 85(8) 975-985
• Shin MK, Jang YH, Yoo HJ, Kang DW, Park MH, Kim MK, Song JH, Kim SD, Min G, Rhyu HK, Choi KY, Bae YS, Min DS. (2011) fMLP promotes osteoblast differentiation via the N-formyl peptide receptor 1-mediated signaling pathway in human mesenchymal stem cells from bone marrow. J. Biol. Chem. 286(19):17133-43
• Jang YH, Min DS (2011) Nuclear localization of phospholipase D1 mediates the activation of nuclear protein kinase C- and extracellular signal-regulated kinase signaling pathways. J. Biol. Chem. 286(6):4680-9
• Kang DW, Choi KY, Min DS. (2011) Phospholipase D meets Wnt signaling: a new therapeutic target. Cancer Research (Invited review) 71:1-6
• Kang DW, Park MH, Lindsley C, Brown HA, Min DS. (2011) Autoregulation of Phospholipase D Activity is Coupled to Selective Induction of Phospholipase D1 Expression to Promote Invasion of Breast Cancer Cells. Int. J. Cancer 128(4):805-16
• Kim BW, Lee JW, Choo HJ, Lee CS, Jung SY, Yi JS, Ham YM, Lee JH, Hong J, Kang MJ, Chi SG, Hyung SW, Lee SW, Kim HM, Cho BR, Min DS, Yoon G, Ko YG. (2010) Mitochondrial oxidative phosphorylation system is recruited to detergent-resistant lipid rafts during myogenesis. Proteomics. 10(13):2498-515
• Kang DW, Min G, Park DY, Hong KW, Min DS (2010) Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells. Exp Mol Med. 42(8):555-64.126. Kang DW, Min DS. (2010) Positive Feedback Regulation between Phospholipase D and Wnt Signaling Promotes Wnt-Driven Anchorage-Independent Growth of Colorectal Cancer Cells. PLoS One. 5(8). pii: e12109.
• Jang JH, Lee TJ, Yang ES, Min DS, Kim YH, Kim SH, Choi YH, Park JW, Choi KS, Kwon TK. (2010) Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1. Exp Cell Res. 316(13):2194-203
• Kang DW, Lee SH, Yoon JW, Park WS, Choi KY, Min DS. (2010) Phospholipase D1 drives a positive feedback loop to reinforce the Wnt/ß-catenin/TCF signaling axis. Cancer Res. 70(10):4233-42
• Kang DW, Min DS (2010) Platelet derived growth factor increases phospholipase D1 but not phospholipase D2 expression via NFkappaB signaling pathway and enhances invasion of breast cancer cells. Cancer Lett. 294(1):125-33
• Kim M, Moon C, Kim H, Shin MK, Min DS, Shin T. (2010) Developmental levels of phospholipase D isozymes in the brain of developing rats. Acta Histochem. 112(1):81-91. (Co-corresponding author)
• Kang DW, Lee JY, Oh DH, Park SY, Woo TM, Kim MK, Park MH, Jang YH, Min DS. (2009) Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells. Exp. Mol. Med. 41(9):678-85.
• Lee TJ, Um HJ, Min DS, Park JW, Choi KS, Kwon TK. (2009) Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Free Radic Biol Med. 46(12):1639-49
• Moon C, Jeong J, Shin MK, Min DS, Shin T. (2009) Expression of phospholipase D isozymes in mouse lungs during postnatal development. J Vet Med Sci. 71(7):965-8. (Co-corresponding author)
• Yoon SH, Min DS, Bae YS. (2009) Over-expression of phospholipase D isozymes down-regulates protein kinase CKII activity via proteasome-dependent CKIIbeta degradation in NIH3T3 cells. Mol. Cells. 27(3):299-305
• Park MH, Ahn, BH, Hong YK, Min DS (2009) Overexpression of Phospholipase D Enhances Matrix Metalloproteinase-2 Expression and Glioma Cell Invasion via Protein Kinase C and Protein Kinase A/NFB/Sp1-mediated Signaling Pathways. Carcinogenesis. 30(2):356-65.
• Lee IB, Kim SK, Chung SH, Kim H, Kwon TK, Min DS, Chang JS. (2008) The effect of rod domain A148V mutation of neurofilament light chain on filament foemation. BMB reports. 41(12):868-874
• Kim MK, Kim SD, Lee HY, Lee SY, Shim JW, Yun J, Kim JM, Min DS, Yoo YH, Bae YS. (2008) Collagen-binding motif peptide, a cleavage product of osteopontin, stimulates human neutrophil chemotaxis via pertussis toxin-sensitive G protein-mediated signaling. FEBS Lett. 582(23-24):3379-3384
• Jang YH, Ahn BH, Namkoong S, Kim YM, Jin JK, Kim YS, Min DS. (2008) Differential Regulation of Apoptosis by Caspase-mediated Cleavage of Phospholipase D isozymes. Cell. Signaling. 20(12):2198-207
• Jang YH, Namkoong S, Kim YM, Lee SJ, Park BJ, Min DS. (2008) Cleavage of phospholipase D1 by caspase promotes apoptosis via modulation of the p53-dependent cell death pathway. Cell Death Differ. 15(11):1782-1793
• Moon C, Kim H, Kim S, Lee Y, Shin MK, Min DS, Shin T.(2008) Transient expression of phospholipase D1 during heart development in rats. J Vet Med Sci. 70(4):411-3. (Co-corresponding author)
• Huh JW, Kim DS, Kang DW, Ha HS, Ahn K, Noh YN, Min DS, Chang KT, Kim HS. (2008) Transcriptional regulation of GSDML gene by antisense-oriented HERV-H LTR element. Arch Virol. 153(6):1201-5
• Shin MK, Kim MK, Bae YS, Jo I, Lee SJ, Chung CP, Park YJ, Min DS. (2008) A novel collagen-binding peptide promotes osteogenic differentiation via Ca(2+)/calmodulin-dependent protein kinase II/ERK/AP-1 signaling pathway in human bone marrow-derived mesenchymal stem cells. Cell Signaling. 20(4):613-24.
• Kang DW, Park MH, Lee YJ, Kim HS, Kwon TK, Park WS, Min DS. (2008) Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/ras/ERK/NFkappa B-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells. J. Biol. Chem. 283(7):4094-4104
• Kim S, Kim H, Lee Y, Hyun JW, Lee YH, Shin MK, Min DS, Shin T. (2007) The expression and cellular localization of phospholipase D isozymes in the developing mouse testis. J. Vet. Sci. 8(3):209-212. (Co-corresponding author)
• Ahn BH, Park MH, Lee YH, Min DS. (2007) Phorbol myristate acetate-induced Egr-1 expression is suppressed by phospholipase D isozymes in human glioma cells. FEBS Lett. 581(30):5940-5944.
• Ahn BH, Park MH, Lee, YH, Kon TK, Min DS (2007) Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. Biochem. Biophys. Acta. Mol. Cell Res. 1773(12) 1721-1731.
• Oh KJ, Lee SC, Choi HJ, Oh DY, Kim SC, Min DS, Kim JM, Lee KS, Han JS. (2007) Role of phospholipase D2 in anti-apoptotic signaling through increased expressions of Bcl-2 and Bcl-xL. J Cell Biochem. 101(6) 1409-1422.
• Lee JY, Choo JE, Choi YS, Lee KY, Min DS, Pi SH, Seol YJ, Lee SJ, Jo IH, Chung CP, Park YJ. (2007) Characterization of the surface immobilized synthetic heparin binding domain derived from human fibroblast growth factor-2 and its effect on osteoblast differentiation. J Biomed Mater Res A. 83(4) 970-979.
• Lee JY, Choo JE, Choi YS, Park JB, Min DS, Lee SJ, Rhyu HK, Jo IH, Chung CP, Park YJ. (2007) Assembly of collagen-binding peptide with collagen as a bioactive scaffold for osteogenesis in vitro and in vivo. Biomaterials. 28(29) 4257-4267.
• Jin JK, Ahn BH, Na YJ, Kim JI, Kim YS, Choi EK, Ko YG, Chung KC, Kozlowski PB, Min DS. (2007) Phospholipase D1 is associated with amyloid precursor protein in Alzheimer's disease. Neurobiol Aging. 28(7) 1015-1027
• Kim MK, Min DS, Park YJ, Kim JH, Ryu SH, Bae YS. (2007) Expression and functional role of formyl peptide receptor in human bone marrow-derived mesenchymal stem cells. FEBS Lett. 581(9):1917-22
• Min DS, Choi JS, Kim HY, Shin MK, Kim MK, Lee MY. (2007) Ischemic preconditioning upregulates expression of phospholipase D2 in the rat hippocampus. Acta Neuropathol (Berl). 114(2):157-162
• Shin SY, Choi HY, Ahn BH, Min DS, Son SW, Lee YH. (2007) Phospholipase Cgamma1 stimulates transcriptional activation of the matrix metalloproteinase-3 gene via the protein kinase C/Raf/ERK cascade. Biochem Biophys Res Commun. 353 (3) 611-616
• 98. Lim JH, Park JW, Min DS, Chang JS, Lee YH, Park YB, Choi KS, Kwon TK. (2007) NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells. Apoptosis. 12(2) 411-421.
• 97. Oh DY, Park SY, Cho JH, Lee KS, Min DS, Han JS. (2007) Phospholipase D1 activation through Src and Ras is involved in basic fibroblast growth factor-induced neurite outgrowth of H19-7 cells. J. Cell Biochem. 101 (1) 221-234.
• 96. Kim H, Lee J, Kim S, Shin MK, Min DS, Shin T. (2007) Differential expression of phospholipases D1 and D2 in mouse tissues. Cell Biol Int. 31(2) 148-155(Co-corresponding author)
• 95. Oh NS, Yoon SH, Lee WK, Choi JY, Min DS, Bae YS. (2007) Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes cell proliferation. Gene. 386(1-2):147-53
• Jin JO, Park HY, Kim JW, Park JI, Hong YS, Min DS, Kwak JY. (2007) Phosphatidic acid induces the differentiation of human acute promyelocytic leukemic cells into dendritic cell-like. J. Cell Biochem. 100 (1) 191-203
• Kim EJ,Sung JY, Lee HJ, Rhim H, Hasegawa M, Iwatsubo T, Min DS, Kim J, Paik SR, Chung KC. (2006) Dyrk1A phosphorylates alpha -synuclein and enhances intracellular inclusion formation. J. Biol. Chem. 281, 33250- 33257
• Park HJ, Kim SS, Seong YM, Kim KH, Goo HG, Yoon EJ, Min DS, Kang S, Rhim H. (2006) Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease: Implications for the physiological function of HtrA2 in the mitochondria. J. Biol. Chem. 281, 33250-33257
• Jin JK, Kim NH, Lee YJ, Kim YS, Choi EK, Kozlowski OB, Park MH, Kim HS, Min DS (2006) Phospholipase D1 is up-regulated in the mitochondrial fraction from the brains of Alzheimer’s disease patients. Neuroscience Lett. 407(3):263-7.
• Sin HS, Huh JW, Kim DS, Kang DW, Min DS, Kim TH, Ha HS, Kim HH, Lee SY, Kim HS. (2006) Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells. Arch Virol. 151(10):1985-94
• Huh JW, Kim TH, Yi JM, Park ES, Kim WY, Sin HS, Kim DS, Min DS, Kim SS, Kim CB, Hyun BH, Kang SK, Jung JS, Lee WH, Takenaka O, Kim HS. (2006) Molecular evolution of the periphilin gene in relation to human endogenous retrovirus m element. J. Mol. Evol. 62(6):730-737
• Lee SY, Kim JW, Jin JO, Song MG, Park JI, Min DS, Kwak JY. (2006) Delayed apoptosis and modulation of phospholipase D activity by plasmid containing mammalian cDNA in human neutrophils. Biochem Biophys Res Commun. 347(4):1039-47
• Lee TJ, Kim YH, Min DS, Park JW,Kwon TK. (2006) Se-methylselenocysteine enhances PMA-mediated CD11c expression via phospholipase D1 activation in U937 cells. Immunobiology. 211(5):369-76.
• Ahn BH, Min G, Bae YS, Bae YS, Min DS (2006) Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells. Exp Mol Med. 38(1):55-62.
• Lee J, Kim H, Ahn M, Min DS, Shin T. (2006) Immunohistochemical localization of phospholipase D1 in the retina of pigs. Neurosci Lett. 397(1-2):44-7.
• Um JW, Min DS, Rhim H, Kim J, Paik SR, Chung KC. (2006) Parkin ubiquitinates and promotes the degradation of RanBP2. J. Biol. Chem. 281(6):3595-603
• Kim JM, Lee YH, Kwon TG, Chang JS, Chung KC, Min DS (2006) Phospholipase D Prevents Etoposide-Induced Apoptosis by Inhibiting the Expression of Egr-1 and PTEN. Cancer Research. 66(2):784-93.
• Lee JO, Kwun HJ, Jung JK, Choi, KH, Min DS, Jang KL (2005) Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. Oncogene. 24(44):6617-25.
• Kim HJ, Choi JS, Lee YM, Shim EY, Hong SH, Kim MJ, Min DS, Rhie DJ, Kim MS, Jo YH, Hahn SJ, Yoon SH (2005) Fluoxetine inhibits ATP-induced [Ca(2+)](i) increase in PC12 cells by inhibiting both extracellular Ca(2+) influx and Ca(2+) release from intracellular stores. Neuropharmacology. 49(2):265-74.
• Kang J, Ahn M, Moon C, Min DS, Matsumoto Y, Shin T (2005) Phospholipase D1 is up-regulated in the retina of Lewis rats with experimental autoimmune uveoretinitis. Immunol Invest. 34(1):27-36.
• Jin JK, Kim NH, Min DS, Kim JI, Choi JK, Jeong BH, Choi SI, Choi EK, Carp RI, Kim YS. (2005) Increased expression of phospholipase D1 in the brains of scrapie-infected mice. J Neurochem. 92(3):452-61.
• Chang JS, Kim SK, Kwon TK, Bae SS, Min DS, Lee YH, Kim SO, Seo JK, Choi JH, Suh PG. (2005) Pleckstrin homology domains of phospholipase C-gamma 1 directly interact with beta -tubulin for activation of phospholipase C-gamma 1 and reciprocal modulation of beta -tubulin function in microtubule assembly. J Biol Chem. 280(8):6897-905
• Kim MD, Min DS, Sim KB, Cho HJ, Shin T. (2004) Expression and potential role of phospholipase D1 in cryoinjured cerebral cortex of rats. Histol Histopathol. 19(4):1015-9.
• Kim SK, Wee SM, Chang JS, Kwon TK, Min DS, Lee YH, Suh PG. (2004) Point mutations in the split PLC-gamma1 PH domain modulate phosphoinositide binding. J Biochem Mol Biol. 30;37(6):720-725.
• Kim JM, Choi BH, Jang KL, Min DS (2004) Phospholipase D activity is elevated in hepatitis C virus core protein-transformed NIH3T3 mouse fibroblast cells. Exp. Mol. Med. 36 (5): 1-7
• Lee SY, Oh JY, Lee MJ, Jang MJ, Park HY, Kim JW, Min DS, Bae YS, Kwak JY. (2004) Anti-apoptotic mechanism and reduced expression of phospholipase D in spontaneous and Fas-stimulated apoptosis of human neutrophils. Eur J Immunol. 34(10):2760-2770.
• Kim MJ, Ryu G, Kang JH, Sim SS, Min DS, Rhie DJ, Hahn SJ, Kim MS, Jo YH (2004) Inhibitory effects of epicatechin on interleukin-1beta-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation. Biochem Pharmacol. 68(9):1775-1785.
• Kim MJ, Sim SS, Min DS, Rhie DJ, Hahn SJ, Yoon SH, Kim MS, Jo YH (2004) Changes in IP3 receptor are ssociated with altered calcium response to cholecystokinin in diabetic rat pancreatic acini. Pancreas 29(4):e106-112.
• Kim MD, Min DS, Sim KB, Cho HJ, Shin T. (2004) Expression and potential role of phospholipase D1 in cryoinjured cerebral cortex of rats. Histol Histopathol. 19(4):1015-1019.
• Kim SY, Ahn BH, Min KJ, Lee YH, Joe EH, Min DS. (2004) Phospholipase D Isozymes Mediate Epigallocatechin Gallate-induced Cyclooxygenase-2 Expression in Astrocyte Cells. J. Biol. Chem.279(37):38125-38133.
• Kim SY, Ahn BH, Kim J, Bae YS, Kwak JY, Min G, Kwon TK, Chang JS, Lee YH, Yoon SH, Min DS. (2004) Phospholipase C, protein kinase C, Ca/calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells. Eur J Biochem. 271(17):3470-3480.
• Kim SY, Min DS, Choi JS, Choi YS, Park HJ, Sung KW, Kim J, Lee MY. (2004) Differential expression of phospholipase D isozymes in the hippocampus following kainic acid-induced seizures. J Neuropathol Exp Neurol. 63(8):812-820.
• Shin SY, Kim CG, Ko J, Min DS, Chang JS, Ohba M, Kuroki T, Choi YB, Kim YH, Na DS, Kim JW, Lee YH. (2004) Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation. J Mol Biol. 340(4):681-693.
• Park SS, Eom YW, Kim EH, Lee JH, Min DS, Kim S, Kim SJ, Choi KS. (2004) Involvement of c-Src kinase in the regulation of TGF-beta1-induced apoptosis. Oncogene. 23(37):6272-6281.
• Kang HK, Lee HY, Lee YN, Jo EJ, Kim JI, Kim GY, Park YM, Min DS, Yano A, Kwak JY, Bae YS. (2004) Up-regulation of phospholipase Cgamma1 and phospholipase D during the differentiation of human monocytes to dendritic cells. Int Immunopharmacol. 4(7):911-920.
• Jang MJ, Lee MJ, Park HY, Bae YS, Min DS, Ryu SH, Kwak JY (2004) Phosphorylation of phospholipase D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase. Exp Mol Med. 36(2):172-178.
• Kim J, Min G, Bae YS, Min DS. (2004) Phospholipase D is involved in oxidative stress-induced migration of vascular smooth muscle cells via tyrosine phosphorylation and protein kinase C. Exp Mol Med. 36(2):103-109.
• Choi JS, Park HJ, Jo YC, Chun MH, Chung JW, Kim JM, Min DS, Lee MY (2004) Immunohistochemical localization of phospholipase D2 in embryonic rat brain. Neurosci. Lett. 357, 147-151.
• Ahn, M., Lee Y., Sim, K. B., Min, D. S., Matsumoto, Y., Wie, M. B., Shin, Y. G., Shin, T. (2004) Increased Expression of Phospholipase D in the Heart with Experimental Autoimmune Myocarditis in Lewis Rats. Immunol Invest. 33, 95-105
• Yang EJ, Yoon JH, Min DS, Chung KC. (2004) LIM kinase 1 activates CREB during the neuronal differentiation of immortalized hippocampal progenitor cells. J Biol Chem. 279, 8903-8910
• Woo JH, Lim JH, Kim YH, Suh SI, Min DS, Chang JS, Lee YH, Park JW, Kwon TK. (2004) Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction. Oncogene. 23, 1845-1853
• Kim HJ, Yum KS, Sung JH, Rhie DJ, Kim MJ, Min DS, Hahn SJ, Kim MS, Jo YH, Yoon SH. (2004) Epigallocatechin-3-gallate increases intracellular [Ca(2+)] in U87 cells mainly by influx of extracellular Ca(2+) and partly by release of intracellular stores. Naunyn Schmiedebergs Arch Pharmacol. 369, 260-267
• Choi JS, Choi BH, Ahn HS, Kim MJ, Rhie DJ, Yoon SH, Min DS, Jo YH, Kim MS, Sung KW, Hahn SJ. (2003) Mechanism of block by fluoxetine of 5-hydroxytryptamine3 (5-HT3)-mediated currents in NCB-20 neuroblastoma cells. Biochem Pharmacol. 66(11):2125-32.
• Choi BH, Choi JS, Ahn HS, Kim MJ, Rhie DJ, Yoon SH, Min DS, Jo YH, Kim MS, Hahn SJ. (2003) Fluoxetine blocks cloned neuronal A-type K+ channels Kv1.4. Neuroreport. 14(18):2451-2455.
• Woo JH, Kim YH, Choi YJ, Kim DG, Lee KS, Bae JH, Min DS, Chang JS, Jeong YJ, Lee YH, Park JW, Kwon TK. (2003) Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis. 24(7):1199-208.
• Kwun HJ, Lee JH, Min DS, Jang KL. (2003) Transcriptional repression of cyclin-dependent kinase inhibitor p21 gene by phospholipase D1 and D2. FEBS Lett. 544(1-3):38-44.
• Rhie DJ, Sung JH, Ha US, Kim HJ, Min DS, Hahn SJ, Kim MS, Jo YH, Yoon SH. (2003) Endogenous somatostatin receptors mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells. Brain Res. 975(1-2):120-8.
• Ahn, BH., Kim, SY, Kim, EH, Choi, KS, Kwon, TK, Lee, YH, Chang, JS, Kim, MS, Jo, YH, and Min, DS. (2003) Transmodulation between PLD and c-Src enhances cell proliferation. Mol. Cell. Biol. 23, 3103-3115
• Kim MJ, Ryu GR, Chung JS, Sim SS, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH. (2003) Protective effects of epicatechin against the toxic effects of streptozotocin on rat pancreatic islets: in vivo and in vitro. Pancreas. 26(3):292-9.
• Jung, K., Min, DS., Sim, K.-B., Ahn, M., Kim, H., Cheong, J., and Shin, T. (2003) Upregulation of phospholipase D1 in the spinal cords of rats with clip compression injury. Neuroscience Lett. 336, 126-130.
• Shin SY, Ko J, Chang JS, Min DS, Choi C, Bae SS, Kim MJ, Hyun DS, Kim JH, Han MY, Kim YH, Kim YS, Na DS, Suh PG, Lee YH. (2002) Negative regulatory role of overexpression of PLC gamma 1 in the expression of early growth response 1 gene in rat 3Y1 fibroblasts. FASEB J. 6(12):1504-1514.
• Min DS, Shin EY, Kim EG. (2002) The p38 mitogen-activated protein kinase is involved in stress-induced phospholipase D activation in vascular smooth muscle cells. Exp. Mol. Med. 34(1):38-46.
• Ahn BH, Rhim H, Kim SY, Sung YM, Lee MY, Choi JY, Wolozin B, Chang JS, Lee YH, Kwon TK, Chung KC, Yoon SH, Hahn SJ, Kim MS, Jo YH, Min DS (2002) Alpha-synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney 293 cells. J. Biol. Chem. 277, 12334-12342
• Ko J, Kim IS, Jang SW, Lee YH, Shin SY, Min DS, Na DS. (2002) Leukotactin-1/CCL15-induced chemotaxis signaling through CCR1 in HOS cells. FEBS Lett. 515(1-3):159-164.
• Choi BH, Choi JS, Rhie DJ, Yoon SH, Min DS, Jo YH, Kim MS, Hahn SJ. (2002) Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor. Am J Physiol Cell Physiol. 282(6):C1461-1468.
• Chang JS, Seok H, Kwon TK, Min DS, Ahn BH, Lee YH, Suh JW, Kim, JW, Iwashita S, Omori A, Ichinose S, Numata O, Seo JK, Oh YS, Suh PG. (2002) Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity. J. Biol. Chem. 277(22):19697-19702.
• Lee EJ, Min DS, Lee MY, Chung JW, Chun MH, Oh SJ. (2002) Differential expression of phospholipase D1 in the developing retina. Eur J Neurosci. 15(6):1006-1012.
• Lee MY, Choi YS, Choi JS, Min DS, Chun MH, Kim ON, Lee SB, Kim SY. (2002) An immunohistochemical study of APG-2 protein in the rat hippocampus after transient forebrain ischemia. Brain Res. 924(2):237-241.
• Sim SS, Choi JC, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim CJ, Kim MS, Jo YH. (2002) Effect of ethanol on spontaneous phasic contractions of cat gastric smooth muscle. Scand. J. Gastroenterol 37(1):23-27.
• Min DS, Kwon TK, Park WS, Chang JS, Park SK, Ahn BH, Ryoo ZY, Lee YH, Lee YS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH.(2001) Neoplastic transformation and tumorigenesis associated with overexpression of phospholipase D isozymes in cultured murine fibroblasts. Carcinogenesis. 22(10):1641-1647.
• Min DS, Ahn BH, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH. (2001) Expression and regulation of phospholipase D during neuronal differentiation of PC12 cells. Neuropharmacology. 41(3):384-391.
• Denmat-Ouisse LA, Phebidias C, Honkavaara P, Robin P, Geny B, Min DS, Bourgoin S, Frohman MA, Raymond MN. Regulation of constitutive protein transit by phospholipase D in HT29-cl19A cells. J. Biol Chem. 2001 276(52):48840-48846.
• Shin, S. Y., Kim, S .Y., Kim, H. H., Min, DS., Ko, J., Kang, U-G., Kim, Y. S., Kwon, T. K., Han, Kim, Y. H. and Lee, Y. H. (2001) Induction of early growth response-1 gene expression by calmodulin antagonist trifluoperazine through the activation of Elk-1 in human fibrosarcoma HT1080 cells. J. Biol. Chem. 276, 7797-7805.
• Sung, J. Y., Lee, S. Y., Min, DS., Um, T. Y., Ahn, Y. S., Choi, M-U., Kim, Y., Chung, K. C. (2001) Differential activation of phospholipase C and D by mitogenic EGF and neurogenic PDGF in immortalized hippocampal stem cell lines. J. Neurochem. 78(5):1044-1053.
• Min DS, Lee KH, Chang JS, Ahn BH, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH. (2001) Altered expression of phospholipase D1 in spontaneously hypertensive rats. Mol Cells. 30;11(3):386-391.
• Min DS, Ahn BH, Jo YH. (2001) Differential tyrosine phosphorylation of phospholipase D isozymes by hydrogen peroxide and the epidermal growth factor in A431 epidermoid carcinoma cells. Mol. Cells. 30;11(3):369-378.
• Min DS, Choi JS, Chun MH, Chung JW, Lee MY. (2001) Transient expression of phospholipase D1 in developing rat hippocampus. Neurosci Lett. 214;310(2-3):125-128.
• Lee. J. S., Min, DS., Park, C., Park, C. S. and Cho, N. J. (2001) Phytosphingosine and C2-phytoceramide induce cell death and inhibit carbachol-stimulated phospholipase D activation in Chinese hamster ovary cells expressing the Caenorhabditis elegans muscarinic acetylcholine receptor. FEBS Lett. 499, 82-86.
• Lee, E. J., Min, DS., and Chun, M. H. (2001) Expression and cellular localization of phospholipase D1 in murine retina. Brain Research, 905, 240-244.
• Ahn M, Min DS, Kang J, Jung K, Shin T. (2001) Increased expression of phospholipase D1 in the spinal cords of rats with experimental autoimmune encephalomyelitis. Neurosci Lett. 18;316(2):95-98.
• Shin EY, Min DS, Shin JC, Shin KS, Hyun MS, Ha KS, Kim HS, Ahn HY, Kim EG. (2001) Involvement of phospholipase D in oxidative stress-induced necrosis of vascular smooth muscle cells. FEBS Lett. 16;508(2):277-281
• Park JW, Choi YJ, Suh SI, Baek WK, Suh MH, Jin IN, Min DS, Woo JH, Chang JS, Passaniti A, Lee YH, Kwon TK. Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity. Carcinogenesis. 22(10):1633-1639.
• Choi BH, Choi JS, Min DS, Yoon SH, Rhie DJ, Jo YH, Kim MS, Hahn SJ. (2001) Effects of (-)-epigallocatechin-3-gallate, the main component of green tea, on the cloned rat brain Kv1.5 potassium channels. Biochem Pharmacol. 62(5):527-535.
• Choi BH, Choi JS, Yoon SH, Rhie DJ, Min DS, Jo YH, Kim MS, Hahn SJ. (2001) Effects of norfluoxetine, the major metabolite of fluoxetine, on the cloned neuronal potassium channel Kv3.1. Neuropharmacology. 41(4):443-453.
• Rhie DJ, Kim MJ, Choi WS, Lee KH, Sung JH, Min DS, Yoon SH, Hahn SJ, Kim MS, Jo YH. (2001) Effect of somatostatin on cholecystokinin-induced amylase release in rat pancreatic acini. Pancreas. 23(1):102-108.
• Choi J, Choi BH, Hahn SJ, Yoon SH, Min DS, Jo Y, Kim M. (2001) Inhibition of Kv1.3 channels by H-89 (N--[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) independent of protein kinase A. Biochem. Pharmacol. 61(8):1029-1032.
• Sim SS, Choi JC, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim CJ, Kim MS, Jo YH. (2001) The involvement of phospholipase A(2) in ethanol-induced gastric muscle contraction. Eur. J. Pharmacol. 413(2-3):281-285.
• Sim SS, Kim YC, Shim HS, Choi JC, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH. (2001) Involvement of cyclic GMP in nitric-oxide-induced gastric relaxation Comparison of the actions of cyclic GMP and cyclic AMP. Scand J Gastroenterol. 36(1):16-22.
• Kim MJ, Lee KH, Min DS, Yoon SH, Hahn SJ, Kim MS, Jo YH. (2001) Distributional patterns of phospholipase C isozymes in rat pancreas. Pancreas. 22(1):47-52.
• Kim, M-J., Lee, K-H., Min, DS., Yoon, S. H., Hahn, S. J., Kim, M-S., and Jo, Y. H. (2001) Site-specific localization of protein kinase C isoforms in rat pancreas. Pancreatology. 1. 36-42
• Min DS, Cho NJ, Yoon SH, Lee YH, Hahn SJ, Lee KH, Kim MS, Jo YH. (2000) Phospholipase C, protein kinase C, Ca(2+)/calmodulin-dependent protein kinase II, and tyrosine phosphorylation are involved in carbachol-induced phospholipase D activation in Chinese hamster ovary cells expressing muscarinic acetylcholine receptor of Caenorhabditis elegans. J. Neurochem. 75(1):274-281.
• Min DS, Kim MJ, Jeong HK, Lee YH, Kim H, Shin HS, Ryu SH, Suh PG. (2000) Immunological characterization of 130 kDa phospholipase C-beta 4 isozyme in rat cerebellar Purkinje cells. Neurosci Lett. 29;292(1):9-12.
• Lee, MY., Jo, YH., Chun, MH., Chung, JW., Kim, MS. and Min, DS. (2000) Immunohistochemical localization of phospholipase D1 in rat central nervous system. Brain Research. 864, 52-59.
• Lee MY, Kim SY, Min DS, Choi YS, Shin SL, Chun MH, Lee SB, Kim MS, Jo YH. (2000) Upregulation of phospholipase D in astrocytes in response to transient forebrain ischemia. Glia. 30(3):311-317.
• Chang, J. S. Lee, H., and Min, DS. (2000) Tyrosine phosphorylation of paxillin during cell adhesion. J. Biochem. Mol. Biol. 33, 349-352.
• Min DS, Shin KS, Kim EG, Kim SR, Yoon SH, Kim MS, Jo YH. (1999) Down-regulation of phospholipase D during differentiation of mouse F9 teratocarcinoma cells. FEBS Lett. 9;454(3):197-200.
• Lee WK, Kim JK, Seo MS, Cha JH, Lee KJ, Rha HK, Min DS, Jo YH, Lee KH. (1999) Molecular cloning and expression analysis of a mouse phospholipase C-delta1. Biochem Biophys Res Commun. 261(2):393-399.
• Bae CD, Min DS, Fleming IN, Exton JH. (1998) Determination of interaction sites on the small G protein RhoA for phospholipase D. J. Biol Chem. 273(19):11596-11604.
• Park SK, Min DS, Exton JH. (1998) Definition of the protein kinase C interaction site of phospholipase D. Biochem Biophys Res. Commun. 244(2):364-367.
• Kim MJ, Min DS, Ryu SH, Suh PG. (1998) A cytosolic, galphaq- and betagamma-insensitive splice variant of phospholipase C-beta4. J. Biol. Chem. 273(6):3618-3624.
• Min DS, Kim EG, Exton JH. (1998) Involvement of tyrosine phosphorylation and protein kinase C in the activation of phospholipase D by H2O2 in Swiss 3T3 fibroblasts. J. Biol. Chem. 273(45):29986-29994.
• Min DS, Exton JH. (1998) Phospholipase D is associated in a phorbol ester-dependent manner with protein kinase C-alpha and with a 220-kDa protein which is phosphorylated on serine and threonine. Biochem Biophys Res Commun. 248(3):533-537.
• Min DS, Park SK, Exton JH. (1998) Characterization of a rat brain phospholipase D isozyme. J. Biol. Chem. 273(12):7044-7051.
• Kim D, Jun KS, Lee SB, Kang NG, Min DS, Kim YH, Ryu SH, Suh PG, Shin HS. (1997) Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature. 389(6648):290-3.
• Kim HS, Lee YH, Min DS, Chang JS, Ryu SH, Ahn BY, Suh PG. (1995) Tyrosine phosphorylation of phospholipase C-gamma 1 by vaccinia virus growth factor.Virology. 214(1):21-8
• Lee YH, Lee HJ, Lee SJ, Min DS, Baek SH, Kim YS, Ryu SH, Suh PG. (1995) Down-regulation of phospholipase C-gamma 1 during the differentiation of U937 cells. FEBS Lett. 358(2):105-8.
• Min DS, Kim Y, Lee YH, Suh PG, Ryu SH. (1993) A G-protein-coupled 130 kDa phospholipase C isozyme, PLC-beta 4, from the particulate fraction of bovine cerebellum. FEBS Lett. 331(1-2):38-42.
• Kim MJ, Bahk YY, Min DS, Lee SJ, Ryu SH, Suh PG. (1993) Cloning of cDNA encoding rat phospholipase C-beta 4, a new member of the phospholipase C.Biochem Biophys Res Commun. 194(2):706-12.
• Min DS, Kim DM, Lee YH, Seo J, Suh PG, Ryu SH. (1993) Purification of a novel phospholipase C isozyme from bovine cerebellum. J. Biol Chem. 268(16):12207-12